基于CiteSpace的肠易激综合征实验机制可视化分析

Visualization Analysis of Experimental Mechanism of Irritable Bowel Syndrome Based on CiteSpace

目的利用可视化知识图谱分析软件CiteSpace分析肠易激综合征近10年实验研究领域的现状与热点及趋势,为以后研究方向提供参考。方法以2008—2018年中国知网数据库收录的615篇肠易激综合征实验研究相关文献为研究对象,采用CiteSpace软件对纳入文献进行作者、机构、关键词的可视化知识图谱分析,探索肠易激综合征实验研究现状与热点。结果肠易激综合征实验机制研究发文量呈增长趋势,最突出的是王德山、王艳杰团队等,对肠易激综合征实验研究关注较密切的机构有北京中医药大学、辽宁中医药大学、广州中医药大学等。研究干预措施主要有方剂、针灸、单味中药或提取物以及西药类。主要研究方向有胃肠动力学、胃肠高敏感性、脑肠肽的调节作用、神经系统的调节作用、免疫机制的调节以及其他等6个方面。结论肠易激综合征实验机制研究力量分散,缺乏多机构间的广泛合作,优势得不到有效整合。干预措施缺乏横向研究,未系统研究多个机制通路,建议开展更为广泛和深入的合作研究。

Objective To analyze the current status,hotspots and trends of experimental research in the field of irritable bowel syndrome in the past 10 years using the visual knowledge mapping software CiteSpaceand provide reference for future research directions.Methods A total of 615 articles of experimental literature on irritable bowel syndrome were collected from the China Knowledge Network database from 2008 to 2018.The CiteSpace software was used to analyze the knowledge,authors,institutions and keywords of the literature.The current status and hotspots of experimental research on syndromes were analyzed.Results The experimental mechanism of irritable bowel syndrome showed an increasing trend.The most prominent ones were WANG Deshan and WANG Yanjie.The institutions with close attention to experimental research on irritable bowel syndrome were Beijing University of Chinese Medicine,Liaoning University of Traditional Chinese Medicine and Guangzhou University of Chinese Medicine,etc.The research interventions mainly included prescriptions,acupuncture,single-flavor Chinese medicine or extractsand western medicines.The main research directions included gastrointestinal kinetics,gastrointestinal hypersensitivity,regulation of brain gut peptide,regulation of nervous system,regulation of immune mechanism and other aspects.Conclusion The research mechanism of irritable bowel syndrome is scattered,and there is a lack of extensive cooperation among multiple institutions.The advantages are not effectively integrated.The interventions is short of horizontal research,systematically studied multiple mechanisms,and need more extensive and in-depth collaborative research.