摘要
Background The cardiac extracellular matrix(ECM)undergoes ongoing modification following myocardial infarction(MI),driving the inflammation and repair response.Collagens,the major component of ECM,regulate the healing process uniquely after MI,where they are synthesized and accumulated to form scars in the infarcted area.Various types of collagens affect the repair response in different ways.Knowing the exact processes of collagen regulation can facilitate the development of new therapeutic options for associated disorders.In this review,we summarize the roles of various collagen types in heart repair after injury.
作者
叶敏
叩珊
严磊
张辉
YE Min;KOU Shan;YAN Lei;ZHANG Hui(School of Life Science and Technology,Shanghai Tech University,Shanghai 201210,China)
基金
sponsored by grants from the National key R&D Program of China(No.2018YFA0108100)
National Natural Science Foundation of China(No.32200592,No.92268103)
the Chinese Postdoctoral Science Foundation(No.2021TQ0328,No.2022M710144)
Shanghai Rising-Star Program(No.20QA1406900)
the Shanghai Tech University start-up fund
