Research progress on the relationship between human cartilage glycoprotein 39(YKL-40) and cardiovascular disease

Background Cardiovascular disease(CVD)is a common cause of death in China.There have been many evidences that inflammatory factors and acute phase reactants play an important role in the pathogenesis of coronary heart disease and acute coronary syndromes,and their related factors may become indicators for predicting and diagnosing early cardiovascular disease.Recent evidence has shown that human cartilage glycoprotein 39(YKL-40)is related to metabolic disorders caused by inflammatory diseases and heart diseases.YKL-40 is a new type of inflammation marker.Studies have shown that YKL-40 can further aggravate vascular damage and can be used as a biomarker for assessing the severity of cardiovascular disease and judging the prognosis.This article reviewed the biological characteristics of YKL-40 and its relationship with cardiovascular diseases.[S Chin J Cardiol 2021;22(1):57-64]