肠道及其菌群老化与老化相关疾病

Aging of intestine and its flora with aging related diseases

正常的胃肠道功能是营养和药物吸收及抵御致病菌的基础。老化相关的肠道功能出现选择性下降,可能会影响营养状况及生活质量。老化同样伴随肠道微生物菌群的改变,而微生物菌群及微生物组与老化相关性疾病(比如衰弱、肥胖症、糖尿病、肌少症、心血管疾病、神经系统疾病等)密切相关。微生物群及微生物组与老化相关疾病相互关联,调控老年人的微生物群和微生物组有望成为干预老化相关疾病的一种创新策略。肠道菌群主要由饮食决定,对老年人进行饮食控制和结构优化,有利于维持健康的胃肠道微生物菌群,从而改善老化相关疾病易感性。

Normal gastrointestinal function is the basis of nutrition and drug absorption and resistance to pathogenic bacteria.Selective decline of aging related intestinal function may affect nutritional status and quality of life.Aging is also associated with changes in intestinal microflora.Microbiota and microbial communities are closely related to aging related diseases such as weakness,obesity,diabetes,muscular diseases,cardiovascular diseases,neurological diseases,etc.Microbiota and microbiome are interrelated with aging related diseases.Regulating the microbiota and microbiome of the elderly is expected to become an innovative strategy to intervene aging related diseases.Intestinal flora is mainly determined by diet.Dietary control and structural optimization for the elderly are conducive to maintaining a healthy gastrointestinal microbiota,so as to improve the susceptibility to aging related diseases.