肠道微生态与高血压并发症

Intestinal microecology and hypertension complications

高血压是一种常见的慢性心血管疾病,与遗传因素、环境因素及其共同作用有关。脑卒中、心肌梗死、心力衰竭及高血压性肾病等是高血压的主要并发症,致残、致死率高。越来越多的证据表明,肠道菌群与高血压并发症存在相关性。肠道菌群失调和细菌代谢产物在高血压并发症的病理生理过程中发挥着重要作用。尽管目前尚缺乏肠道微生态与高血压并发症的大规模临床研究,但肠道菌群及其代谢产物有可能成为高血压并发症治疗的新靶点。本文就肠道微生态与高血压并发症的相关研究进行综述,以期为临床提供参考。

Hypertension is a common chronic cardiovascular disease,which is associated with a combination of genetic and environmental factors.Stroke,myocardial infarction,heart failure and hypertensive kidney disease are the main complications of hypertension with high morbidity and mortality.More and more evidence shows that there is a correlation between intestinal flora and hypertension complications.Intestinal flora imbalance and bacterial metabolites play an important role in the pathophysiological process of hypertension complications.Although there is no large-scale clinical study on intestinal microecology and hypertension and its complications,intestinal flora and its metabolites may become a new target for the treatment of hypertension complications.This article reviews the interaction between intestinal microecology and hypertension complications,in order to provide reference for clinical practice.