老年患者动脉粥样硬化性肾动脉狭窄的危险因素分析

Analysis of risk factors for arteriosclerosis renal artery stenosis

目的探讨老年动脉粥样硬化性肾动脉狭窄(arteriosclerosis renal artery stenosis,ARAS)的危险因素。方法选取2016年1月至2019年6月在宁阳县第一人民医院接受肾动脉彩超检查的老年患者140例。比较ARAS患者与非ARAS患者的临床资料,将单因素分析(t检验或χ2检验)差异有统计学意义的指标纳入Logistic回归模型进行多因素分析。结果140例老年患者中ARAS 68例(ARAS组),无ARAS 72例(非ARAS组)。ARAS组患者高血压病史和糖尿病病史所占比例、年龄以及同型半胱氨酸、超敏C反应蛋白水平明显高于非ARAS组患者,差异有统计学意义(χ2=3.657、3.897,t=-2.970、3.989、-3.360;P<0.05)。Logistic回归分析显示,年龄、高血压病史及HCY、hs-CRP水平是老年ARAS的独立危险因素[OR(95%CI)=1.077(1.019-1.138)、4.814(2.006-11.552)、1.072(1.026-1.119)、1.345(1.190-1.520),P<0.01]。结论及早发现高危患者,并针对性改善危险因素,对于ARAS的治疗和预后有着重要的临床意义。

Objective To investigate the risk factors of arteriosclerosis renal artery stenosis(ARAS)in aged patients.Methods 140 elderly patients underwent renal artery color doppler ultrasound examination at First People’s Hospital of Ningyang County from January 2016 to June 2019 were selected.The clinical data of ARAS patients and non-ARAS patients were compared.The indicators with statistically significant difference in univariate analysis(T test or chi-square test)were incorporated into Logistic regression model for multivariate analysis.Results Among the 140 patients,68 patients were ARAS(ARAS group)and 72 patiens were non-ARAS(non-ARAS group).The age,the proportion of hypertension history and diabetes history,the levels of homocysteine(HCY)and hypersensitive C-reactive protein(hs-CRP)in the ARAS group were significantly higher than those in the non-ARAS Group(χ2=3.657,3.897;t=-2.970,3.989,-3.360;P<0.05).Logistic regression analysis showed that age,hypertension history,HCY level and hs-CRP level were the independent risk factors[OR(95%CI)=1.077(1.019-1.138),4.814(2.006-11.552),1.072(1.026-1.119),1.345(1.190-1.520),P<0.01]in elderly patients with ARAS.Conclusion Early detection of high risk patients and targeted improvement of risk factors have important clinical significance for the treatment and prognosis of ARAS.