双相情感障碍患者P波和QT离散度改变

Change and clinical significance of P wave and QT interval dispersion in patients with bipolar disorder

目的探讨双相情感障碍(BD)患者P波离散度和QT离散度变化及临床意义。方法选取2020年10月至2021年10月期间在我院精神科住院符合双相情感障碍诊断的患者129例,设为BD组。另选取同时期本院121例体检健康人群作为对照组。对两组进行常规12导联同步心电图检查,测量并比较两组的P波离散度和心率校正的QT间期(QTc)离散度。结果双相情感障碍组患者P波最小时间和QTc最小时间小于对照组,P波最大时间、P波离散度和QTc离散度高于对照组(均p<0.01)。两组QTc最大时间无统计学差异(p>0.05)。结论双相情感障碍患者P波离散度和QTc离散度均升高。P波离散度和QTc离散度的测定对BD患者罹患心血管疾病的评估有重要临床意义。

Objective To investigate the changes and clinical significance of P wave dispersion and QT dispersion in patients with bipolar disorder(BD).Methods A total of 129 patients who were hospitalized in the psychiatric department of our hospital and met the diagnosis of bipolar disorder from October 2020 to October 2021were selected as the BD group.Another 121 healthy people with physical examination in our hospital during the same period were selected as the control group.Routine 12-lead synchronous electrocardiogram was performed in the two groups,and the P wave dispersion and heart rate-corrected QT interval(QTc)dispersion were measured and compared between the two groups.Results The minimum time of P wave and the minimum time of QTc in the BD group were shorter than those of the control group,and the maximum time of the P wave,the dispersion of P wave and the dispersion of QTc were higher than those of the control group(all p<0.01).There was no statistical difference in the maximum time of QTc between the two groups(p>0.05).Conclusions Both P wave dispersion and QT interval dispersion are increased in BD patients.The measurement of P wave dispersion and QT interval dispersion has important clinical significance for the evaluation of cardiovascular disease in BD patients.