冠心病患者血清中MOTS-c水平及其与冠状动脉病变严重程度的关系

Changes of serum MOTS-c in patients with coronary heart disease and its relationship with degree of coronary artery stenosis

目的:观察冠心病(CHD)患者血清线粒体衍生肽MOTS-c水平,分析其与冠状动脉(冠脉)病变严重程度的关系,探讨其临床意义。方法:选取行冠脉造影(CAG)的患者60例,其中稳定型心绞痛(SAP)20例(SAP组)、急性心肌梗死(AMI)20例(AMI组),CAG正常者20例(NC组)。采用酶联免疫吸附试验(ELISA)测定血清MOTS-c水平。结果:与NC组比较,SAP组和AMI组患者血清MOTS-c水平均明显降低,且AMI组患者血清MOTS-c水平显著低于SAP组,差异均有统计学意义(P<0.05)。CHD患者血清MOTS-c水平与Gensini积分呈负相关(r=-0.354,P=0.025)。CHD患者血清MOTS-c与低密度脂蛋白(LDL)水平呈正相关(r=0.411,P=0.008)、与总胆固醇(TC)水平呈正相关(r=0.373,P=0.018),而与年龄、BMI、收缩压、舒张压、尿素氮、肌酐、空腹血糖(FBG)、三酰甘油(TG)、高密度脂蛋白(HDL)、白细胞计数(WBC)、左室射血分数(LVEF)、BNP无显著相关性(P>0.05)。结论:低水平的MOTS-c可能与CHD的发生、发展相关。MOTS-c可能通过多方面的机制保护内皮及延缓动脉粥样硬化的发生,是CHD的潜在保护因素,或将成为治疗CHD的新靶点。

Objective:To measure the level of serum mitochondrial derived peptide MOTS-c in patients with coronary heart disease(CHD)and analyze the relationship between it and the degree of coronary artery stenosis.Method:The study involved 20 individuals with acute myocardial infarction(AMI),20 individuals with stable angina pectoris(SAP),and 20 healthy individuals as controls.The level of serum MOTS-c was measured by enzyme-linked immunosorbent assay(Elisa).Result:The serum MOTS-c level in SAP group and AMI group was significantly lower than that in NC group,and the serum MOTS-c level in AMI group was significantly lower than that in SAP group(P<0.05).There was a negative correlation between serum MOTS-c level and Gensini score in patients with CHD(r=-0.354,P=0.025).There was a positive correlation between serum MOTS-c level and LDL-C level(r=0.411,P=0.008)and between serum MOTS-c level and TC level(r=0.373,P=0.018)in CHD patients.There was no significant correlation between serum MOTS-c level with age,BMI,systolic blood pressure,diastolic blood pressure,urea nitrogen,creatinine,FBG,TG,HDL,WBC,LVEF,BNP(P>0.05).Conclusion:Low levels of MOTS-c may be associated with the occurrence and development of CHD.MOTS-c may protect the endothelium and delay the occurrence and development of atherosclerosis through a variety of mechanisms.It may be a protective factor of cardiovascular system and a new potential target for the treatment of CHD.