羟氯喹联合复方倍他米松注射液治疗口腔扁平苔藓的疗效分析

Analysis of the efficacy of hydroxychloroquine combined with betamethasone injection in the treatment of oral lichen planus

目的:分析羟氯喹联合复方倍他米松注射液治疗口腔扁平苔藓的疗效。方法:采用随机分组的方法将213名口腔扁平苔藓患者均分为3组,分别进行羟氯喹组(单纯使用羟氯喹治疗)、倍他米松组(单纯使用复方倍他米松治疗)、联合组(羟氯喹联合复方倍他米松治疗)的处理。比较各组患者基本情况、治疗前后血清相关生化指标含量、临床疗效、预后复发情况以及临床不良反应发生情况的差异。结果:3组患者治疗前后IL-17、IFN-γ、IL-6含量差异显著(P<0.05),治疗后所有患者IL-17、IL-6含量明显下降,而IFN-γ含量明显上升。治疗后联合组IL-17、IL-6含量显著低于羟氯喹组和倍他米松组,IFN-γ含量显著高于羟氯喹组和倍他米松组。联合组临床疗效显著优于羟氯喹组和倍他米松组(P<0.05)。联合组患者治疗4个月后、6个月后复发情况显著低于羟氯喹组和倍他米松组(P<0.05)。联合组患者胃肠道反应、血压升高不良反应显著高于羟氯喹组和倍他米松组(P<0.05)。结论:单纯使用羟氯喹治疗或单纯使用复方倍他米松治疗,对于治疗口腔扁平苔藓有一定疗效,羟氯喹联合复方倍他米松治疗的效果更佳,值得临床推广。

Objective:To investigate the efficacy of hydroxychloroquine combined with betamethasone injection in the treatment of oral lichen planus.Methods:Totally 120 patients with oral lichen planus(OLP)were divided into three groups,separately hydroxychloroquine group(simple use of hydroxychloroquine treatment),betamethasone group(using pure compound betamethasone treatment)and combination group(hydroxychloroquine+compound betamethasone).The contents of biochemical indicators before and after treatment in the three groups were compared.The clinical efficacy,recurrence and adverse reactions of the three groups after treatment were compared.Results:The contents of IL-17,IFN-γand IL-6 were significantly different in the three groups before and after treatment(P<0.05).With the time migration,the content of IL-17 and IL-6 showed a significant decrease,and IFN-γgamma content showed a significant upward trend.The levels of IL-17 and IL-6 in the combined group were significantly lower than that in hydroxychloroquine group and betamethasone group,and the amount of IFN-γwas significantly higher than that of hydroxychloroquine group and betamethasone group.The clinical efficacy of the combined group was significantly better than that of hydroxychloroquine group and betamethasone group(P<0.05).After 4 months and 6 months after treatment,the recurrence was significantly lower than that of hydroxychloroquine group and betamethasone group(P<0.05).The adverse reactions of gastrointestinal reaction and blood pressure in the combined group were significantly higher than that of hydroxychloroquine group and betamethasone group(P<0.05).Conclusion:Using pure hydroxychloroquine or pure compound betamethasone treatment for OLP patients has certain curative effect,and the effect of hydroxychloroquine joint compound betamethasone treatment is better,worthy of clinical promotion.