艾滋病合并弥漫大B细胞淋巴瘤和艾滋病合并伯基特淋巴瘤的临床影像特征

Clinical and Imaging Features of AIDS-Related Diffuse Large B-Cell Lymphoma and Burkitts Lymphoma

目的探究艾滋病合并弥漫大B细胞淋巴瘤(AR-DLBCL)和艾滋病合并伯基特淋巴瘤(AR-BL)的临床及影像差别。方法多中心回顾性分析104例AR-DLBCL和42例AR-BL患者的临床影像资料及预后。结果AR-BL更容易出现病灶融合(P=0.02)。AR-DLBCL病变CT平扫(P=0.002)和增强CT(P=0.017)纹理多表现为均匀,中度强化比AR-BL常见(P=0.004)。AR-BL病变平扫CT和增强CT纹理不均匀者常见,绝大多数病灶为轻度强化。两组患者的临床指标、累及部位和进展/死亡时间并无显著差异。结论CT平扫和增强CT图像的纹理和强化程度有助于初步判断AR-NHL的病理类型,若纹理均匀、中度强化则考虑AR-DLBCL,若病灶融合、纹理不均匀、轻度强化则考虑AR-BL。

Objective To investigate the clinical and imaging differences between AIDS-related diffuse large B cell lymphoma(AR-DLBCL)and AIDS-related Burkitt’s lymphoma(AR-BL).Methods This multicenter retrospective study compared the clinical,imaging and prognosis information of 104 AR-DLBCL and 42 AR-BL patients.Results Fusion tendency was more commonly seen in AR-BL(P=0.02).The textures of AR-DLBCL lesions were prone to show homogeneous both in plain scans(P=0.002)and contrast enhanced scans(P=0.017),and the moderate enhancement was more common than AR-BL(P=0.004).The textures of AR-BL lesions were common for heterogeneous in plain and enhanced scans,and most lesions showed poor enhanced.There was no significant difference in clinical parameters,sites involved and progression/death time between the two groups.Conclusion The textures of plain and enhanced scans and degree of enhancement in CT images are helpful to make preliminary judgment for the pathological type of AIDS-related nonHodgkin’s lymphoma(AR-NHL).AR-DLBCL is given more consideration if the texture is homogeneous and moderately enhanced.AR-BL is given more consideration if the texture is heterogeneous and poorly enhanced.