摘要
目的探讨应用心脏磁共振组织追踪技术(CMR-TT)定量评估心肌淀粉样变性(CA)患者左室心肌应变的价值。方法对29例CA患者(CA组)及32名正常者(对照组)行3.0 T CMR检查,将电影序列导入CMR后处理软件CVI42,得到基本心功能参数及左室整体及各段(心尖、中间及基底段)的平均3D纵向应变峰值(LS)、周向应变峰值(CS)、径向应变峰值(RS),对这些参数进行比较分析,并将总体应变参数与左室射血分数(LVEF)进行相关性分析,最后根据LVEF将CA患者分为LVEF≥50%及<50%两组后分析其差异,并同对照组进行比较。结果CA组的整体及各段的RS、CS、LS均低于对照组(P均<0.05);且CA组左室整体RS、CS、LS与LVEF均有相关性(r=0.605、0.683、0.423,P均<0.05);LVEF≥50%及<50%CA组的整体RS、CS、LS均低于对照组。结论CMR-TT技术能够定量评估CA患者的左室心肌形变特征,其应变参数能够较LVEF更敏感地检测到心肌功能受损。
Objective to evaluate the value of CMR tissue tracking(CMR-TT)in quantitation of myocardium deformation in patients with cardiac amyloidosis(CA).Methods A total of 29 subjects with CA(CA group)and 32 healthy subjects(control group)underwent 3.0 t cardiac magnetic resonance CMR scanning.The cine sequence was imported into CVI 42 post-processing software for cardiac function and strain analysis.Cardiac function and left ventricular 3 D radial strain(RS),circumferential strain(CS),longitudinal strain(LS)were measured.Then the correlation between the Global strain parameters and left ventricular ejection fraction(LVEF)were analyzed.Then CA patients were divided into CA group with LVEF≥50%and CA group with LVEF<50%.They were compared with the control group.Results The global,average basal,mid-LV and apical segmental RS,CS and LS were significantly lower than those in the control group(all P<0.05).In addition,the GRS,GCS and GLS of CA group were correlated with LVEF(r=0.605,0.683,0.423,all P<0.05).GRS,GCS and GLS of CA group with>50%LVEF and the CA group with LVEF<50%were lower than those of the control group(all P<0.05).Conclusion CMR-TT is conducive to quantitatively evaluate myocardial deformation in patients with CA,and myocardial strain parameters permits earlier detection of LV functional impairment than LVEF.
作者
郭杨钰
谭利华
曾牧
姜孟春
谢幸芷
邓淇予
GUO Yangyu;TAN Lihua;ZENG Mu(The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第5期908-912,共5页
Journal of Clinical Radiology
基金
国家科学基金青年科学基金项目资助(编号81701660)