侵袭性真菌性脑脓肿1例

Invasive fungal brain abscess: a case report

1病例报告患者,男58岁,因急性髓细胞白血病(M2)入住我院血液科。于2016年12月9日开始行2周期化疗、3次腰穿+鞘注,化疗中、化疗后出现粒细胞缺乏症、血小板减少、出血、Ⅲ/Ⅳ度骨髓抑制及呼吸道感染等,予以输注血小板、红细胞及对症抗感染治疗。患者因年龄较大未行异基因骨髓干细胞移植,2017年3月于外院行非清髓造血干细胞移植治疗1次,治疗后再次出现粒细胞缺乏症。

Mucormycsois,also known as zygomycosis,is an extremely serious acute invasive fungal infection(IFI).The disease progresses rapidly and the mortality rate is high.Even if cured,it may leave behind serious sequelae.Immunocompromise is at high risk of mucormycosis.Rhino-orbital-cerebral mucormycosis(ROCM)is the most common type of mucormycosis.It can manifest as headache,nasal obstruction,exophthalmos,ophthalmoplegia and nerve palsy,loss of vision,arterial embolism,etc.A case of ROCM is reported in this paper.The etiology,course of development,clinical and imaging manifestations and treatment of ROCM are described in detail.