舌下特异性免疫治疗对变应性鼻炎患者的疗效分析

Effect of sublingual immunotherapy on patients with allergic rhinitis

目的:研究舌下特异性免疫治疗(SLIT)对不同严重程度单一过敏和多重过敏变应性鼻炎(AR)患者的疗效。方法:依据体内实验结果将186例接受标准化粉尘螨滴剂进行SLIT治疗2年的AR患者分为单一轻度过敏和多重轻度过敏、单一中度过敏和多重中度过敏、单一重度过敏和多重重度过敏。评估治疗前后患者鼻部症状评分、药物评分、视觉模拟量表评分。结果:治疗前和治疗2年症状评分:单一轻度过敏(5.58±1.68、0.58±0.75),多重轻度过敏(5.34±1.49、0.93±0.75);单一中度过敏(4.68±1.55、0.32±0.63),多重中度过敏(6.26±1.46、0.61±0.67);组内比较均差异有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05)。单一重度过敏(5.00±1.21、0.35±0.61),多重重度过敏(6.24±1.64、0.92±0.72),组内、组间比较均差异有统计学意义(P<0.05)。VAS评分:单一轻度过敏(6.09±1.23、1.52±1.25),多重轻度过敏(6.21±0.90、1.97±1.18);单一中度过敏(6.12±0.53、1.16±1.03),多重中度过敏(6.65±1.08、1.65±0.98);组内比较均差异有统计学意义(P<0.05);组间比较差异无统计学意义(P>0.05)。单一重度过敏(6.26±0.73、1.16±1.13),多重重度过敏(6.49±1.04、1.89±1.07),组内、组间比较均差异有统计学意义(P<0.05);药物评分:各组内比较均差异有统计学意义(P<0.05),各组间差异无统计学意义(P>0.05)。结论:标准化粉尘螨滴剂对单一和多重过敏的AR患者均有疗效,而对于重度多重过敏患者需要延长脱敏治疗疗程(>2年)。

Objective:Study the efficacy of sublingual immunotherapy(SLIT)for monosensitized and polysensitized allergic rhinitis patients of different severity.Method:According to the results of intradermal experiments,186 patients with AR who were treated with standardized dust mites SLIT for 2 years.These patients have been divided into mild monosensitized group and mild polysensitized group,moderate monosensitized group and moderate polysensitized group,severe monosensitized group and severe polysensitized group.Statistics and analysis of total nasal symptom score(TNSS),total medication score(TMS),visual analog scale(VAS)about before and after SLIT treatment.Result:Before SLIT treatment and after 2 years,the TNSS:Mild monosensitized group(5.58±1.68)(0.58±0.75),mild polysensitized group(5.34±1.49)(0.93±0.75);moderate monosensitized group(4.68±1.55)(0.32±0.63),moderate polysensitized group(6.26±1.46)(0.61±0.67),which have showed a statistically significant difference(P<0.05),between the two groups have no significant difference(P>0.05).Severe monosensitized group(6.26±0.73)(1.16±1.13),severe polysensitized group(6.49±1.04)(1.89±1.07),which have showed a statistically significant difference(P<0.05),between the two groups have a statistically significant difference(P<0.05).The VAS:Mild monosensitized group(6.09±1.23)(1.52±1.25),mild polysensitized group(6.21±0.90)(1.97±1.18),moderate monosensitized group(6.12±0.53)(1.16±1.03),moderate polysensitized group(6.65±1.08)(1.65±0.98),which have showed a statistically significant difference(P<0.05),between the two groups have no significant difference(P>0.05).Severe monosensitized group(6.26±0.73)(1.16±1.13),severe polysensitized group(6.49±1.04)(1.89±1.07),which have showed a statistically significant difference(P<0.05),between the two groups have a statistically significant difference(P<0.05).The TMS:These have showed a statistically significant difference(P<0.05)with same group,between all groups have no significant difference(P>0.05).Conclusion:Dust mites under the SLIT are effective for monosensitized and polysensitized allergic patients.For patients with severe polysensitized,it is necessary to extend the treatment time(>2 years).