移动平台管理对变应性鼻炎儿童皮下特异性免疫治疗依从性及疗效的影响

Effect of mobile platform in improving compliance and efficacy of subcutaneous immunotherapy in children with allergic rhinitis

目的:探索移动平台在改善变应性鼻炎(AR)患儿皮下特异性免疫治疗(SCIT)依从性及疗效中的效果。方法:选取2018年1~6月确诊为AR并接受SCIT的86例患儿为研究对象,根据电脑产生的随机数列将研究对象随机分配入实验组和对照组,每组各43例。对照组接受常规SCIT管理,实验组在常规管理的基础上接受依托智能手机和电脑的移动平台SCIT管理。比较2组SCIT起始期脱落率及达到维持期所用时间,干预前及干预后第6个月的鼻炎症状视觉模拟量表、四分法评分及儿童鼻-结膜炎相关生活质量评分。结果:2组SCIT起始期脱落率差异无统计学意义(P>0.05),实验组达到维持期平均所用时间短于对照组(P<0.05);干预后第6个月时2组鼻炎症状四分法评分差异无统计学意义(P>0.05),鼻炎症状视觉模拟量表及儿童鼻-结膜炎相关生活质量评分差异有统计学意义(P<0.05)。结论:对接受SCIT的AR患儿实施基于移动平台的信息化管理,有助于提高其治疗依从性,改善鼻炎症状。

Objective:To explore effect of mobile platform in improving compliance and efficacy of subcutaneous immunotherapy(SCIT)in children with allergic rhinitis(AR).Method:From January to June 2018,86 children diagnosed with AR and receiving SCIT were selected as research objects.According to the random sequence generated by the computer,the research objects were randomly assigned to the experimental group and the control group,with 43 cases in each group.The control group received conventional SCIT management,while the experimental group received mobile platform SCIT management relying on smart phones and computers.The SCIT shedding rate at the initial stage and the time taken to reach the maintenance period were compared between the two groups,as well as the visual simulation scale of rhinitis symptoms,four-point score and rhinoconjunctivia-related quality of life scores before and at the 6 th month after the intervention.Result:There was no statistically significant difference in the initial SCIT shedding rate between the two groups(P>0.05),and the average duration of the maintenance period of the experimental group was shorter than that of the control group,with statistically significant difference(P<0.05).At the 6 th month after intervention,there was no statistically significant difference in the scores of rhinitis symptoms by the four-point method between the two groups(P>0.05),and there were statistically significant differences in the visual simulation scale of rhinitis symptoms and the scores of children’s rhinoconjunctivia-related quality of life(P<0.05).Conclusion:This study confirmed that the application of a mobile platform is of great significance for improving compliance and the treatment effects of SCIT in children with AR.