1例患儿联用欧龙马滴剂与复方头孢克洛干混悬剂致双硫仑样反应的药物不良反应分析

Analysis of Adverse Drug Reactions of a Child with Disulfiram-Like Reaction Caused by Combined Use of Sinupret Drops and Compound Cefaclor for Suspension

目的:分析医院1例因联用欧龙马滴剂与复方头孢克洛干混悬剂致双硫仑样反应患儿的诊疗经过和相关原因。方法与结果:医院临床医生为1例诊断为鼾症和鼻窦炎的患儿开具了欧龙马滴剂与复方头孢克洛干混悬剂,患儿在同时服用二药10 min后出现双硫仑样反应。医生在询问病史后,考虑欧龙马滴剂辅料中有较高含量的乙醇,遂怀疑此症状可能是因患儿未按注意事项服药所致,随即停用复方头孢克洛干混悬剂,30 min后患儿呼吸困难症状缓解。结论:临床在为相关患者开具处方时,应注意药物间可能存在的相互作用,如头孢菌素与含乙醇药物同时服用可能引发双硫仑样反应,在不能避免联合使用时医生和药师必须详细交代用药注意事项,以避免药物不良反应的发生。

Objective:To investigate the diagnosis and treatment process and related reasons of a child with disulfiram-like reaction caused by combined use of Sinupret Drops and Compound Cefaclor for Suspension in the hospital.Methods and Results:The hospital clinician prescribed Sinupret Drops and Compound Cefaclor for Suspension for one child diagnosed with sleep apnea syndrome and sinusitis,and the patient developed disulfiram-like reaction 10 minutes after taking the two drugs simultaneously.After inquiring about the medical history,the physician believed that the excipients of Sinupret Drops contained a relatively high content of ethanol,and suspected that the symptoms might be caused by the patient's failure to take the medicines according to the matters needing attention.Then the child stopped the Compound Cefaclor for Suspension immediately,and 30 minutes later,the child's dyspnea symptoms were relieved.Conclusion:When prescribing clinically for related patients,attention should be paid to possible drug interactions;for example,taking cephalosporins and ethanol-containing drugs simultaneously may cause disulfiram-like reaction.When combined use cannot be avoided,the physicians and pharmacists should explain the precautions for medication in detail to avoid the occurrence of adverse drug reactions.