厚朴酚与和厚朴酚对肝肾保护作用的研究进展

Research Progress in Protective Effects of Magnolol and Honokiol on the Liver and Kidney

厚朴酚(magnolol)与和厚朴酚(honokiol)是中药厚朴(Magnoliae Officinalis Cortex)的重要有效成分,除具有抗菌、抗病毒、抗肿瘤、降血糖、降血脂等药理作用外,还能对抗变态反应、缺血再灌注、转化生长因子-β、高糖、高脂、四氯化碳(CCl_(4))、对乙酰氨基酚、硫代乙酰胺、磷脂酰乙醇胺、D-氨基半乳糖/脂多糖、H_(2)O_(2)、叔丁基过氧化氢引起的肝损伤和肝纤维化,以及缺血再灌注、输尿管结扎、血管紧张素Ⅱ、高糖、脂多糖、H_(2)O_(2)引起的肾损伤和肾纤维化。厚朴酚与和厚朴酚对肝肾的保护作用可能主要是通过其抗炎和抗氧化作用完成的。该文着重综述了厚朴酚与和厚朴酚对肝肾的保护作用,并对相关研究进行了分析。

Magnolol and honokiol are important active ingredients of the traditional Chinese medicine Magnoliae Officinalis Cortex.In addition to the antibacterial,antiviral,antitumor,hypoglycemic,hypolipidemic and other pharmacological effects,they can resist the liver injury and liver fibrosis caused by allergy,ischemia-reperfusion,transforming growth factor-β,high glucose,high fat,carbon tetrachloride(CCl_(4)),acetaminophen,thioacetamide,phosphatidylethanolamine,D-galactosamine/lipopolysaccharide,H_(2)O_(2)and tert-butyl hydroperoxide,and resist the kidney injury and renal fibrosis caused by ischemia-reperfusion,ureteral ligation,angiotensin II,high glucose,lipopolysaccharide and H_(2)O_(2).The protective effects of magnolol and honokiol on the liver and kidney may be achieved through their anti-inflammatory and antioxidant effects.In this article,the protective effects of magnolol and honokiol on the liver and kidney are reviewed,and the related research is analyzed.