中药厚朴对胃的保护作用及其药理机制的研究进展

Research Progress in Protective Effect of Traditional Chinese Medicine Cortex Magnoliae Officinalis on Stomach and Its Pharmacological Mechanism

厚朴作为传统中药,具有厚肠胃之功效,具体表现为促进胃排空、收缩胃平滑肌、保护胃黏膜、抗溃疡等。其中,厚朴促进胃排空的作用可能与抑制一氧化氮通路、调控胃动素和胃泌素分泌有关;而其收缩胃平滑肌作用可能是通过提高卡哈尔间质细胞的增殖,增强胃电活动而实现的。该文综述了中药厚朴对胃的保护作用及其药理机制,并对相关研究进行了分析。

As a traditional Chinese medicine,cortex magnoliae officinalis has the effect of tonifying the stomach and intestines,such as promoting gastric emptying,contracting gastric smooth muscle,protecting gastric mucosa and preventing ulcer.The effect of promoting gastric emptying may be related to the inhibition of nitric oxide pathway and the regulation of secretion of motilin and gastrin,while the effect of contracting gastric smooth muscle may be achieved by increasing proliferation of Cajal interstitial cells and enhancing gastric electrical activity.This paper summarizes the protective effect of traditional Chinese medicine cortex magnoliae officinalis on stomach and its pharmacological mechanism,and analyzes related studies.