药学干预对化疗患者预防使用质子泵抑制剂的合理性和胃肠道不良反应的影响

Impact of Pharmacological Interventions on the Rationality and Gastrointestinal Adverse Reactions of Prophylactic Use of PPIs in Chemotherapy Patients

目的:分析药学干预对化疗患者预防使用质子泵抑制剂(proton pump inhibitors,PPIs)的合理性和胃肠道不良反应的影响,为临床PPIs的合理使用提供参考。方法:选取2019年12月—2020年11月南通市第六人民医院肿瘤科收治的未进行药学干预的925例肿瘤患者作为非药学干预组,另选取2020年12月—2021年11月医院肿瘤科收治的进行药学干预的480例肿瘤患者作为药学干预组,分析和比较2组患者PPIs的预防使用情况,以及PPIs所致胃肠道不良反应的发生率。结果:药学干预组患者PPIs的预防性使用率低于非药学干预组(78.33%vs 84.76%,P<0.05),但2组患者的不合理用药发生率和PPIs致胃肠道不良反应的发生率经比较其差异均无统计学意义(P>0.05)。结论:药师通过药学干预可以减少肿瘤患者PPIs的预防性使用,但对其预防性使用的合理性和不良反应的发生影响不大。

Objective:To investigate the impact of pharmacological interventions on the rationality and gastrointestinal adverse reactions of prophylactic use of proton pump inhibitors(PPIs)in chemotherapy patients,and to provide reference for the rational use of clinical PPIs.Methods:A total of 925 tumor patients,admitted to the Department of Oncology of the Sixth People’s Hospital of Nantong from December 2019 to November 2020,without pharmacological intervention were selected as the non-pharmacological intervention group,and 480 tumor patients,admitted to the Department of Oncology of the Sixth People’s Hospital of Nantong from December 2020 to November2021,with pharmacological interventions were selected as the pharmacological intervention group.The prophylactic use of PPIs and the occurrence rate of gastrointestinal adverse reactions caused by PPIs in the two groups were analyzed and compared.Results:The prophylactic use rate of PPIs in the pharmacological intervention group was lower than that in the non-pharmacological intervention group(78.33%vs.84.76%,P<0.05),but the differences in the occurrence rate of irrational drug use and of the gastrointestinal adverse reactions caused by PPIs between the two groups were not statistically significant(P>0.05).Conclusion:The prophylactic use of PPIs in oncology patients can be reduced with pharmaceutical interventions performed by pharmacists,but the rationality of their prophylactic use and the occurrence of adverse reactions are not greatly affected.