摘要
MUM1(multiple myeloma oncogene 1)/IRF4(interferon regulatory factor 4)是干扰素调节因子(interferon regulatory factors,IRFs)家族中的一种重要转录因子。MUM1/IRF4可通过影响信号转导,对多种免疫细胞的发育和免疫功能产生重要影响。近年来研究发现,MUM1/IRF4在多种恶性淋巴瘤中存在异常表达,并在淋巴瘤的发生、发展、诊断及预后判断方面发挥重要作用。本文主要就MUM1/IRF4在淋巴瘤中的作用机制进行综述。
MUM1(multiple myeloma oncogene 1)/IRF4(interferon regulatory factor 4)is an important transcription factor in the family of interferon regulatory factors(IRFs),and it exerts important influence on the development and immune function of a variety of immune cells by affecting a series of signal transduction.Recent studies have found that abnormal expression of MUM1/IRF4 can be detected in a variety of lymphatic malignancies.It plays an important role in the occurrence,development,diagnosis and prognosis of lymphoma.This paper mainly reviews the research advances in the mechanism of MUM1/IRF4 in pathogenesis of lymphoma.
作者
马迪
高春记
MA Di;GAO Chunji(Department of Hematology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Nankai University,Tianjin 300071,China)
出处
《解放军医学院学报》
CAS
2020年第3期304-307,共4页
Academic Journal of Chinese PLA Medical School
基金
北京市自然科学基金(7162175)
