摘要
替加环素耐药基因tet(X3)和tet(X4)的出现和传播对公共卫生造成了严重威胁.本文在活禽市场工人的肠道菌群及周围环境样本中检测到tet(X3),tet(X4)和碳青霉烯类基因(如NDM和IMP).研究结果表明,替加环素耐药基因tet(X3)和tet(X4)已经传播至活禽市场环境及健康人的肠道菌群中,很可能从活禽市场进一步传播给消费者、动物及各种生态环境甚至临床相关的病原体.
He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiology.They noted that both tet(X3)and tet(X4)can confer resistance to tigecycline and the newly FDA-approved eravacycline and omadacyclin,which are last-resort antibiotics used to treat multi-drug-resistant(MDR)bacterial infections.Our previous report[2]revealed that live poultry market(LPM)is a huge antibiotic resistance gene(ARG)reservoir,including the mobile colistin resistance(mcr)genes,mcr-1,mcr-3,mcr-4 and mcr-5.Large-scale metagenomic data screening showed that tigecycline resistance gene tet(X3)was widespread in poultry faecal samples collected from China LPMs,whereas it has not been detected in human(n=2019)gut microbiomes[3],which suggested that tet(X3)is previously confined to animal guts or animal-derived bacteria.
作者
王亚楠
刘飞
朱宝利
高福
Yanan Wang;Fei Liu;Baoli Zhu;George Fu Gao(College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China;CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;Chinese Center for Disease Control and Prevention(China CDC),Beijing 102206,China)
基金
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29010000)
the External Cooperation Program of CAS(153211KYSB20160001).
