贻贝黏附蛋白研究进展

Research progress in mussel adhesion proteins

仿生黏附材料具有高强度黏附性、柔韧性、耐水性以及良好的生物可降解性等优点,因此广泛应用于医药和工业制造等领域。海洋生物贻贝的足蛋白(Mfp)是其中最具代表性的天然高强度黏附物质之一,基于它研制的仿生黏合剂已在牙科、骨科和皮肤科等临床治疗中得到广泛应用。该综述对Mfp的种类、形态特性、黏附机制和基因工程制造等方面的研究进行了梳理和阐述,并对其今后的研发和应用趋势进行了展望。

Biomimetic adhesive materials have been widely used in the medicinal field and industrial manufacture due to their advantages of high adhesion,flexibility,water resistance and good biodegradability.Marine mussel foot protein(Mfp)is one of the most representative natural high-strength adhesives and has been intensively applied in the clinical treatment and recovery encompassing dentistry,orthopedics and dermatology.In this paper,the types,morphological characteristics,adhesion mechanism and genetic engineering manufacture of Mfp are reviewed and elucidated.Finally,the future developments and applications of Mfp are outlined.