沉默信息调节蛋白1在糖尿病性肾病发病机制中的作用研究进展

Research progress in sirtuin-1 in involvement the pathogenesis of diabetic nephropathy

糖尿病性肾病是糖尿病严重的微血管并发症之一,是导致终末期肾功能衰竭的主要原因。糖尿病肾病的发病机制极其复杂,最新研究发现,沉默信息调节蛋白1可通过调节代谢平衡、抗凋亡、抗氧化应激及抑制炎症反应等机制对肾脏起保护作用,在糖尿病肾病的发生与发展中起关键作用。深入研究沉默信息调节蛋白1可能为糖尿病肾病的诊断和治疗带来新的方法。该文综述了沉默信息调节蛋白1在糖尿病性肾病发病机制中的作用研究进展。

Diabetic nephropathy is one of the severe microvascular complications associated with diabetes mellitus and the primary cause of the end-stage chronic renal failure. The pathogenesis of diabetic nephropathy is very complicated.According to the latest research,sirtuin-1,which can exert renoprotective effects by modulating metabolic homeostasis,resisting apoptosis and oxidative stress,and inhibiting inflammation,plays a key role in the occurrence and development of diabetic nephropathy. Further study of sirtuin-1 may lead to new approaches to the diagnosis and treatment of diabetic nephropathy.