CD47免疫功能与靶向药物的研究进展

Immune function and targeted drugs of CD47:research advances

CD47是一种广泛表达的跨膜糖蛋白,已有大量研究显示其高表达与多种恶性肿瘤发生发展呈正相关。该文综述了CD47的分子结构、功能和相关药物研发现状,重点讨论了CD47治疗性抗体类药物在抗肿瘤领域的开发及临床研究进展,提出CD47靶点的基础研究及临床应用开发策略。

CD47 is a ubiquitously expressed transmembrane protein on myeloid cells,where its high expression was shown to positive correlation with poor prognosis in many tumors.This article focuses on the development and clinical research progress of CD47 therapeutic antibody in the field of antitumor,and proposes the fundamental and clinical researches strategies for CD47.