摘要
催醒宁,又名优色林,化学名称为1、3、3—三甲基-5-二甲氨基甲酰氧基吲哚满盐酸盐,化学结构式为:催醒宁是一种可逆性胆碱酯酶抑制剂,临床上可用作中麻催醒、治疗青光眼及缩瞳等用药。为解决制剂中催醒宁的含量测定,必须建立一个简便而又专一的定量分析方法。
A reversible cholinesterase inhibitor with eserine--like structure,Cui Xing Ning reacts with nitrous acid to yield an orange product in an acid medium.On the ground of this reaction,a quantitative determination method of Cui Xing Ning has been found.This simple,accurate and specific method has been satisfactorily applied to the preparations of anethesia analeptic.With the aid of identification of the reaction product,nitrosation occurring at Cposition is inferred.The mechanism is simply discussed.
出处
《军事医学科学院院刊》
1982年第2期195-202,共8页
Bulletin of the Academy of Military Medical Sciences