某艾滋病村艾滋病合并肝炎患者肝功能分析

The research on liver function among AIDS patients co-infected with hepatitis in rural areas of Henan province

目的了解艾滋病病毒感染者/艾滋病病人(HIV/AIDS)合并感染丙肝、乙肝及肝功能情况。方法收集河南省某艾滋病村HIV/AIDS患者356例,采用酶联免疫吸附法检测其乙肝表面抗原(HBsAg)、丙肝抗体(HCV-Ab),采用全自动生化分析仪检测肝功能。结果356例HIV/AIDS患者中,合并有丙肝感染335例,感染率为94.10%,其中仅合并丙肝双重感染318例,双重感染率为89.33%;合并乙肝和丙肝三重感染17例,三重感染率为4.78%。是否合并肝炎的HIV/AIDS患者肝功能指标间,未合并乙肝和丙肝、合并丙肝双重感染、合并乙肝和丙肝三重感染HIV/AIDS患者肝功能指标间差异均无统计学意义(P值均>0.05)。除总蛋白(TP)指标外,其他各指标值/异常率均是男性高于女性,其中总胆红素(TB)、直接胆红素(DB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、总蛋白(TP)指标值间差异均有统计学意义(P值均<0.05),ALT、AST、GGT、TP指标异常率间差异均有统计学意义(P值均<0.05)。结论河南省某艾滋病村HIV/AIDS患者合并丙肝感染率偏高,男性肝功能损伤程度高于女性,应开展针对性治疗,促进HIV/AIDS患者身体健康。

Objective To analyze the liver function of patients with HIV/AIDS co-infected with hepatitis C(HCV)and hepatitis B(HBV).Methods A total of 356 HIV/AIDS patients were recruited in an AIDS village in Henan province,who were subjected to HBV and HCV antibody analysis by ELISA,the liver function were detected by automatic biochemical analyzer.Results Among 356 cases of HIV/AIDS,335 cases were co-infected with HCV,the infection rate was 94.10%.Only 318 cases were only co-infected with HCV,the double infection rate was 89.33%.17 cases were co-infected with HBV and HCV,the triple infection rate was 4.78%.Among HIV/AIDS patients with or without HBV and HCV infection,there was no significant difference in hepatic function among patients without infection,or with HCV double infection,or with HBV and HCV triple infection(all P>0.05).Except for indicators of total protein(TP),the values and abnormal rates of other indicators were higher in males than those in females.The differences of total bilirubin(TB),direct bilirubin(DB),alanine aminotransferase(ALT),glutathione transaminase(AST),γ-glutamyl transpeptidase(GGT),total protein(TP)were statistically significant(all P<0.05)There were significant differences in abnormal rates of ALT,AST,GGT and TP(all P<0.05).Conclusion The HCV co-infection rate among HIV/AIDS patients in an AIDS village in Henan province is relatively high.The degree of liver function damage of males is serious than that of females.Targeted treatment should be carried out to promote the health of HIV/AIDS patients.