家兔小肠淋巴集结的发生

DEVELOPMENT OF PEYER’S PATCHES IN RABBITS

家兔小肠淋巴集结(PP)是出生后逐渐发生的。第6天仔兔开始形成PP淋巴样结构,此时能见到T、B两类淋巴细胞,圆顶上皮中已有一定数量的微褶细胞。至第15天,典型的PP淋巴样结构基本形成。随发育进程,PP淋巴样结构更为发达,体积亦逐渐增大。3月龄兔的PP已与成年兔PP的发育程度相当。未见PP随性成熟而退化的现象。家兔PP的发生,与出生后肠道内容物中最初的抗原刺激有关,在PP开始形成时,T、B淋巴细胞和巨噬细胞就同时存在,上述及PP不随性成熟而退化的现象等,均与鸟类法氏囊不同。

In our experiment the typical structure of Peyer’s patches(PP)of rabbits was absent in neonatal animals,but after birth,it developed gradually and rapidly.On the 6 th day,the lymphoid structure of PP appeared and two types of lymphocytes,T and B,were observed in PP.At the same time,there were some microfold cells in the epithelium of the dome.By half a month,the lymphoid structure of PP matured histologically and later on it was more developed and PP gradually increased in size during the growth of the rabbit.The PP of a 3 month old rabbit were similar to those of the mature animals,but no involution of PP appeared at the stage of sexual maturity.The development of PP in rabbits is closely related to the first antigenic stimulation from the intestinal contents,and T,B lymphocytes and macrophages are present at the start of PP formation.In addition,there is no involution of PP in the adult rabbit.These features of PP in rabbits are different from those of the bursa of Fabricius,so it is inappropriate to regard the PP of rabbits as the homologue of the avian bursa of Fabricius.