人胚胎软骨组织内细胞坏死的形态学研究

STUDY ON CELL NECROSIS IN CARTILAGINOUS TISSUE OF HUMAN EMBRYO

收集人工引产或流产胚胎36例(胎龄为64天至8个月),取材自各标本的手指骨,其中尚有20例作了四肢及其他部位骨骺和骨端软骨的组织学切片。观察结果为:1.在胚胎的软骨组织内,不同程度地存在一些软骨细胞散在的退变消失现象及单个软骨细胞残影。2.坏死的软骨细胞可见单个,或者3~10个,有的形成小灶状。3.在部位分布上,增殖层表现比较明显。胎龄愈大,坏死细胞的检出率愈高。4.在残留的软骨细胞影子或细胞核碎片的周围,可见无细胞区及软骨巨细胞。作者认为,上述变化是一种轻微的、生理性的、一过性的形态学变化,甚至可能是一种必然要发生的改变,绝非是病理性的软骨细胞死亡。

Thirty-six aborted embryos ranging from 64 days to 8 months were collected and epiphysial cartilage of the finger and long bones of limbs were studied histologically.The results are as follows:1.Degeneration of cartilage cells of different degrees were seen in the cartilaginous tissues examined.2.Some of the cartilage cells necrosis were alone and others formed a mass of 3 to 5 or from 5 to 10 cells.3.The elder the age of embryo was,the higher the rate of cell necrosis would be.4.There were noncellular regions and giant cells in the normal cartilaginous tissue.The authors consider these changes are rather physiological in nature and would be a necessary process in the development of the cartilage.