棉酚对大鼠下丘脑超微结构影响的观察

ULTRASTRUCTURAL OBSERVATIONS OF THE GOSSYPOL EFFECT ON THE RAT HYPOTHALAMUS

本文观察了棉酚对雄性成年大鼠下丘脑弓状核、视上核和室旁核细胞超微结构的影响。棉酚以每日30mg/kg体重给大鼠灌服,连续5周。结果表明服棉酚后,视上核和室旁核变化不明显;而弓状核中,部分细胞呈现一系列神经分泌功能增强的变化,高尔基复合体和粗面内质网轻度扩张,内充均质低电子密度物质;神经分泌颗粒、溶酶体、核仁样体和微管数量增多。本文并对以上超微结构改变的性质、意义和可能原因进行了讨论。

Observations of the ultrastructural changes in neurons of hypothalamie arcuate,supraoptic and paraventricular nuclei were carried out in the rats following gossypol treatment at a dosage of 30mg/kg/day for 5 weeks.The results showed that after gossypol treatment no marked changes in supraoptic and paraventricular cells could be seen at electron microscopic level,and that there appeared a series of ultrastrucrural changes reflecting increased neurosecretory activity in some of arcuate neurons.They were as follows:Golgi complex and rough endoplasmic reticulum were slightlydilated and filled with homogeneous,low electron density materials in their cisternae;the amounts of neurosecretory granules,lysosomes,nucleolus-like bodies,and microtubules were increased.The nature,significance and cause of these changes are discussed.