大鼠脑干到前额叶皮质的传入投射——WGA-HRP法研究

BRAINSTEM PROJECTIONS TO THE PREFRONTAL CORTEX IN THE RAT——A WGA—HRP STUDY

用WGA-HRP法研究了25只大鼠前额叶皮质的脑干传入投射。在前扣带回背部、前边缘区及岛叶无颗粒皮质背部注射WGA-HRP后,脑干中的逆行标记细胞大致可分为三类。第一类为单胺类神经元集中的核团,其中蓝斑、腹侧被盖区、黑质致密部、中缝背核、中央上核及尾侧线形核等广泛投射到前额叶皮质各部,而外侧网状核、连合核、中缝大核、A_(4)、A_(5)、臂旁核、黑质网状部及颅侧线形核投射到前额叶皮质各部的数量不同。外侧网状核、连合核、中缝大核、A_(4)、A_(5)到前额叶皮质的投射文献上尚未见报道。第二类为与眼肌运动有关的核团,如E-W核、导水管周灰质、中脑网状结构及脑桥吻侧网状核。第三类为与感觉有关的核团,如臂旁核、三叉神经感觉主核及连合核。

The afferent projections of the prefrontal cortex'from the brainstem werestudied by using WGA-HRP technique in 25 rats.Following WGA-HRP injections into the dorsal part of anterior cingulate cortex,prelimbic cortex,and dorsal agranular insular cortex,three groups of retrograde labeled neurons were observed in the brainstem.First group was the monoaminergic neurons,in which the locus coeruleus,ventral tegmental area,compact part of substantia nigra,nucleus raphe dorsalis,nucleus eentralis superior,nucleus linearis caudalis widely projected to the every part of the prefrontal cortex,but the quantitative difference of the projections to different parts of the prefrontal cortex from the lateral reticular nucleus,commissural nucleus,nucleus raphe magnus,A_(4),A_(5),parabrachial nuclei,reticular part of substantia nigra and the nucleus linearis rostralis was also found.Second group was the nuclei related with oculomotor action,such as E-W nucleus,periventricular gray substance,reticular formation of mesencephalon and the nucleus pontis oralis.Third group was-the sensory nucleus,such as parabrachial nucleus,main sensory nucleus of the trigeminal nerve and the commissural nucleus.