肋间神经——脊髓移植的实验研究

AN EXPERIMENTAL STUDY OF INTERCOSTAL NERVE—SPINAL CORD IMPLANTATION

对10只成年狗和2只猴施行肋间神经—脊髓移植及同侧脊髓半横断。术后出现伤侧或双侧后肢瘫,1~2周后功能恢复。于124~366天的不同时期,切断移植神经,4只动物又出现与第一次术后同样的后肢瘫。组织学检查证明这4只动物移植的肋间神经在脊髓内。说明移植的神经对维持后肢运动有一定作用。植入神经末端在脊髓内有丰富的纤维生长。它们分布于距神经末端一定范围的灰质和白质中。移植神经与远段脊髓灰质神经元的直接联系是恢复脊髓功能的解剖学基础。肋间神经—脊髓移植术的效果取决于对手术适应证的掌握和手术本身是否成功。

An intercostal nerve-spinal cord implantation and semitransection of the spinalcord at the point between the origin and insertion of the intercostal nerve was madeon ten adult dogs and two monkeys.One to two weeks after this operation,paraly-tic legs following semitransection of the spinal cord recoverded from the paralysis.The implanted nerves were cut during the different period from 124 to 366 days.The function of the legs of four animals which had recovered paralysed again aftersurgical section of implanted nerve.Histologically,the inserted nerves in the spinalcord were recognized in these animals.Many of the growing fibers extended fromdistal end of the inserted intercostal nerve into the gray and white matter ofthe distal segment of the spinal cord.It is considered that the efficacy of the inter-costal nerve-spinal cord implantation depends upon the choice of the symptomaticindications and the success of the implantation procedure.