针刺大白鼠对视上核、蓝斑内胆碱酯酶、去甲肾上腺素的变化及其与痛阈的关系

CHANGES OF CHOLINESTERASE,NOREPINEPHRINE IN NUC.SUPRAOPTICUS AND LOCUS COERULEUSOF RATS FOLLOWING ELECTRO-ACUPUNCTURE AND THEIR RELATION TO PAIN THRESHOLD

下丘脑是和调节内脏活动有密切相关的植物性高级中枢。视上核则是下丘脑中最大核团之一。一些工作表明视上核与针刺镇疼作用有关系。如电刺激视上核及附近部位可引起动物痛阈升高[1],损毁家兔下丘脑视上核后,电针引起的痛阈升高幅度较小[2],另外还有报道家兔在电针麻醉诱导期可见视上核内神经分泌发生变化[3],以上均说明视上核参与针刺作用。

The present study is designed to investigate the histochemical changes of cholinesterase,norepinephrine in nuc.Supraopticus and locus coeruleus of rats following electo-acupuncture and their possible relation to pain threshold.The preliminary results indicated that the elevation of pain threshold following electro-acupuncture concomittantly with increase in histochemical reaction of cholinesterase,and norepinephrine both in nuc.Supraopticus and locus coeruleus of electro-acupunctured rats.The increase in intensity was shown to be correlated with the elevation of pain threshold.The intensity of increased cholinesterase activity was more obvious in the animals with pain threshold elevated for above two folds than those elevated only one fold.On the other hand,the higher intensity of norepinephrine was obser ed in locus coeruleus with one fold of elevation of pain threshold.The significance of the changes in these two nuclei and their possibld function were briefly discussed.