摘要
棉酚对男性是具有一定抗生育作用的^([1]),经多方面有关资料的介绍,及根据我们实验材料的观察也得到证实^([2~4])。棉酚的作用环节主要是损伤早期精子细胞和粗线期精母细胞;而对间质细胞可能有轻度影响。睾丸是受垂体促性腺激素的调节,包括促卵泡激素(FSH)和促黄体激素(LH)。这两种激素又受下丘脑分泌的促卵泡素释放激素(FRH)及促黄体素释放激素(LRH)的影响。我们根据棉酚对睾丸作用的情况,认为对垂体和下丘脑有进一步研究和探索的必要。另外,肾上腺是一种高度敏感和应激的器官,对性腺也有密切的关系。因此我们也观察了肾上腺皮质的组织化学变化,作为研究棉酚作用的辅助。
Nineteen male rats(body weight 150~350mg)were divided into five groups,3~4 for each group.Gossypol(30mg/kg/day)was administered in 4 groups for various time du-rations(1,2,3,4 weeks).One group for control and distilled water was given instead.The animals were killed by decapitation.We have observed,the cell bodies of FSH gon-adotropes showed slight enlargment after administration of gossypol for 2-weeks.But LH gonadotropes,TSH cells and acidophils showed no cytological changes.The following changes were observed after administration of gossypol for 3-weeks:The FSH gonadotropes were more hypertrophic,contained a few secretory granules and a large nucleus with a prominent nucleolus.These cells increased in number.The LH gonadotropes showed the same but slighter changes than the FSH gonadotropes.The se-cretory granules of TSH cells decreased in number.No obvious changes were seen in the acidophils.The nerve cells in the paraventricular nucleus were degranulated,and con-tained a large vesicular nucleus.No such changes were observed in neurons of the arcu-ate and supraoptic nuclei.The cells in zone fasciculata and reticularis of adrenal cortex swelled.The lipoid,ascorbic acid and acid phosphatase activity decreased in these cells.Zone glomerulosa and zona intermedia remaided unchanged.
作者
袁德霞
刘新月
曹玉纯
王静一
傅志良
Yuan Dexia;Liu Xinyue;Cao Yuchun;Wang Jingyi;Fu Zhiliang(Hebei Medical College)
出处
《解剖学报》
CAS
1980年第3期331-336,347-348,共8页
Acta Anatomica Sinica