电针镇痛对尾核突触超微结构作用的电子显微镜观察

ELECTRON MICROSCOPIC OBSERVATION ON THE EFFECT OF ACUPUNCTURE ANALGESIA ON THE ULTRASTRUCTURE OF SYNAPSES OF CAUDATE NUCLEUS

近年来多数资料表明,尾核对痛与针刺麻醉的镇痛作用有关。刺激尾核可以使痛阈升高^([1])。刺激尾核头部的背侧部位能抑制痛反应^([2])。尾核头部参与电针一定穴位的镇痛过程^([3])。但有关电针镇痛对尾核突触作用的实验研究,迄今尚未见报道。本实验应用电子显微镜方法,试图观察尾核头部在电针镇痛过程中其突触超微结构的变化,并与镇痛的关系。

The ultrastructures of synapses in the head of caudate nuclei of rats were studied by means of electron microscopic technique.The experimental group of rats,in which the pain threshold was elevated after electro-acupuncture,showed no change of the number of the granular vesicles,but a significant decrease of the number of clear synaptic vesicles(without dense core)in the presynaptic boutons.This might be correlated to release of acetylcholine in the synapse.