肾上腺素能神经纤维——影响家兔实验性胃溃疡耳廓皮肤电阻的重要因素

ADRENERGIC NERVE FIBERS-THE CHIEF FACTOR AFFECTING THE CHANGES OF ELECTRIC RESISTANCE OF THE RABBIT PINNA IN EXPERIMENTAL PEPTIC ULCER.

中医的经络学说认为经络是人体内脏与体表互相联系的道路,当内脏有疾患时在体表经络穴位上有相应的反应,如电阻降低、出现压痛点;针刺经络穴位可以治疗内脏的疾病。本研究的目的是用动物实验探索这种体表与内脏的联系是否确实存在;如果存在,这种联系的实质是什么。首先在家兔的内脏用实验方法造成疾患,在疾患过程中探测耳廓皮肤的电阻变化。扫描探测的范围是耳廓的凹面皮肤。探测的仪器是高频皮肤电阻测量仪(550千周/秒)。

Twenty rabbits,divided into 4 groups,with excision of different nerve supplies to the right ear or the right common carotid artery,were induced to develop peptic ulcer by means of injection of 40%acetic acid to the submucosa of stomach.During the period of peptic ulcer,only the group of animals with the excision of superior cervical sympathetic ganglion,all the sensory nerves to the right ear and a segment of right common carotid artery showed a conspicuous reduction of the number of low electric resistance points LERP on the concave surface of the right ear.Histochemical examination of the innervation of the right ear has found almost entirely disappearance of the adrenergic nerves,and the presence of acetylcholinesterase(AGHE)positive nerves in various amounts but apparently reduced in the right ear.Animals of other groups,with partial denervation of the right ear or excision of the right common caroted artery,showed no significant difference in the number of LERP appearing on the affected ear as compared with the normal left during peptic ulcer.And the same is true in the distribution of the adrenergic nerve fibers on both ears.While the AChE-positive nerve fibers showed various degrees of reduction or no difference.The results of the survey of the electric resistance and histochemical studies,indicate that the presence of the adrenergic nerve fibers is closely related to the appearance of LERP on the rabbit ears during peptic ulcer.The meridian theory of the traditional Chinese medicine considers that:"the twelve meridians are internally attributed to viscera and externally associated to appendages".In our experiments,after complete disappearance of the adrenergic nerve fibers of the right ear,the number of LERP appeared on the right ear reduced about one half of that of the left during peptic ulcer;while these nerves were intact,the right ear was able to reflect the disease normally.The sympathetic nerves is one of the chief factors in the association of the viscera with the superficial parts of the body and in this particular case,the peptic ulcer in stomach with ear skin.This association is realized by a visceral regulatory system in the organism which activity is concretely represented by the frequency curve of the daily appearance of LERP on the pinna during peptic ulcer and it fits well to the theme of the classical concept of meridians.