核糖核酸酶对于活体鼠肝细胞的作用

IN VIVO ACTION OF RIBONUCLEASE ON THE MOUSE LIVER CELLS

核醣核酸酶结晶体的溶液由腹膜腔或血管注射到活鼠的体内可引肝细胞皮质部分的核醣核酸的分解和钙质的消失。这种作用在注射後12分钟开始到124小时後肝细胞恢复常态。关於在活体肝细胞内核醣核酸和钙结合的可能性予以充分的讨论。

A solution of crystalline ribonuclease was injected intraperitoneally andintravenously into the blood stream of the mouse.A depletion of the ribonucleicacid together with a decrease of the calcium ash was observed in the corticalportion of the liver cell 12 minutes after the injection until recovery of normaldistribution 122 hours later.The possible association of calcium with ribonucleicacid in the cytoplasm constituents of the liver cell is discussed.