摘要
目的:探讨沙生植物牛心朴子提取物对急性疼痛和慢性疼痛的镇痛活性,为其传统应用提供药效学证据。方法:采用胶原诱导的大鼠CIA模型,对其抗炎镇痛活性进行评价。结果:慢性疼痛CIA大鼠与Model组比较,牛心朴子给药组的缩足反射潜伏期明显延长,三个剂量组的机械缩足反射阈值显著升高。结论:牛心朴子对急性疼痛和慢性炎性疼痛都有显著的抑制作用。
Objective:This study was designed to investigate the analgesic effects of Ethno-Medicine Cynanchum komarovii on acute pain and chronic pain,which provided pharmacological evidence for its traditional application.Method:Rat CIA model induced by collagen.The anti-inflammatory and analgesic activities were evaluated.Results:Comparison of chronic pain CIA rats and model group,tthe latency of foot retraction reflex in niuxinpuzi group was significantly prolonged,and the threshold of mechanical foot retraction reflex in the three dose groups was significantly increased.Conclusions:TACK has a significant inhibitory effect on both acute pain and chronic inflammatory pain.
作者
周丽
王瑞洲
赵世鹏
陶丽
郝福生
马燕
金晶
韩璐
ZHOU Li;WANG Ruizhou;ZHAO Shipeng(College of Pharmacy,Ningxia Medical University,Ningxia,Yingchuan 750004 China)
出处
《疾病监测与控制》
2021年第6期421-423,426,共4页
Journal of Diseases Monitor and Control
基金
宁夏自然科学基金项目(2008AAC03093)
关键词
牛心朴子
类风湿性关节炎
慢性炎性疼痛
镇痛
民族药
cynanchum komarovii
rheumatoid arthritis
chronic inflammatory pain
analgesia
Ethno-Medicine
