Nucleic Acids-based Functional Nanomaterials for Bioimaging

Nucleic acids-based functional nanomaterials in biological imaging have drawn more and more attention in recent years.The rapid development of various nanomaterials provides nucleic acids more possibility to achieve the recognition and bioimaging of different small moleculars in living cells.Coupling of nucleic acids and various nanomaterials obviously enhances the cell uptake efficiency of nucleic acids and the signal amplification strategies of nucleic acids have successfully expanded the applications of nucleic acids-based functional nanomaterials for the detection of trace small molecules in living cells,like microRNAs,proteins,and so on.This review summarizes the recent progresses of nucleic acids-based functional nanomaterials in the application of bioimaging with different amplification mechanism and the recent rapid development of stimulate-response nucleic acids-based nanomaterial for time-spatial controlled imaging of intracellular targets.The advantages of these nucleic acids-based functional nanomaterials and possibility of future development of bioimaging are discussed from the perspective of biological imaging.