清热利湿化痰方联合达格列净治疗2型糖尿病疗效观察

Clinical observation of Qing’re Lishi Huatan Decction and dapagliflozin on type 2 diabetes

目的观察清热利湿化痰方、达格列净联合治疗2型糖尿病(T2DM)患者临床疗效。方法将我院150例T2DM患者随机分为治疗组与对照组各75例。对照组采用达格列净治疗,治疗组采用清热利湿化痰方联合达格列净治疗。比较两组疗效,空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMAIR)、空腹胰岛素(FINS)水平,体质量指数(BMI),全身骨矿含量、全身脂肪含量腿部、躯干和全身肌肉含量,甘油三酯(TG)、总胆固醇(TC)、脂联素水平。结果治疗后,治疗组总有效率高于对照组(P<0.05);两组FBG、HbA1c、HOMA-IR、FINS、BMI、全身脂肪、TG、TC水平均低于治疗前(P<0.05),对照组全身骨矿含量、腿部、躯干和全身肌肉含量与治疗前比较差异无统计学意义(P>0.05),治疗组FBG、HbA1c、HOMA-IR、FINS、BMI、全身脂肪、腿部、躯干和全身肌肉含量、TG、TC水平均低于对照组治疗组全身骨矿含量高于对照组(P<0.05)。结论清热利湿化痰方联合达格列净能显著改善T2DM患者血糖血脂水平,降低全身脂肪含量,提高骨矿和肌肉含量,降低肥胖程度。

Objective To observe the effect of Qingre Lishi Huatan Decoction combined with dapagliflozin on the bone mineral and muscle content of patients with type 2 diabetes(T2DM).Methods A total of 150 patients with T2DM were randomly divided into treatment group and control group,75 cases in each group.Control group was treated with dapagliflozin,while treatment group was treated with Qing’re Lishi Huatan Decoction on the basis of control group.The curative effects of the two groups were compared,including Glucose test,fasting blood sugar(FBG),glycated hemoglobin,insulin resistance index(HOMA-IR),fasting insulin(FINS),body mass index(BMI),bone mineral content,body fat content,leg,trunk and body muscle content,triglyceride(TG),total cholesterol(TC),and adiponectin levels.Results After treatment,the total effective rate of treatment group was higher than that of control group(P<0.05);the FBG,HbA1c,HOMA-IR,FINS,BMI,whole body fat,TG,and TC levels in both groups were lower than before treatment,and were lower in treatment group than control group(P<0.05);control group had no statistically significant difference in total body bone mineral content,leg,trunk,and whole body muscle content compared to before treatment(P>0.05);the overall bone mineral content of treatment group was higher than that of control group(P<0.05).Conclusion Qing’re Lishi Huatan Decoction combined with dapagliflozin can significantly improve the blood glucose and lipid levels of T2DM patients,reduce the body fat content,increase the bone mineral and muscle content,and reduce obesity.