推拿背腰部膀胱经穴对慢性疲劳综合征患者血清IL-6、CHRM1含量的影响及临床疗效观察

Effect and Clinical Efficacy of Posterior Lumbar Bladder Acupoint Massage on IL-6 and CHRM1 Content of Chronic Fatigue Syndrome

目的观察推拿背腰部膀胱经对慢性疲劳综合征(CFS)患者血清白介素-6(IL-6)、乙酰胆碱M1型受体(CHRM1)含量的调节及临床疗效,为推拿治疗慢性疲劳综合征提供细胞因子水平的理论依据。方法选择符合美国疾病控制与预防中心1994年修订的CFS诊断标准的患者60例,随机分为推拿组与针刺组各30例,推拿组采用推拿背腰部膀胱经法治疗,针刺组采用针刺背俞穴法治疗。观察两组患者治疗前后疲劳量表(FS-14),焦虑自评量表(SAS)和抑郁量表(DSI)的评定分值及血清IL-6、CHRM1含量的变化。结果两组CFS患者经过不同方法治疗后生活质量均较治疗前提高,推拿组在改善CFS患者临床症状和健康状况、缓解疲劳及提高临床疗效方面优于单纯针刺法,差异比较具有统计学意义(P<0.01);两组患者治疗前后血清IL-6、CHRM1水平均显著降低(P<0.05,P<0.01),组间比较,推拿组降低更明显(P<0.05)。结论推拿背腰部膀胱经对CFS患者有较好的治疗作用,其效果优于单纯针刺法;推拿对IL-6、CHRM1细胞因子具有调节作用,推拿治疗CFS患者的机理可能与降低血浆的IL-6、CHRM1含量有关。

Objective To observe the effect of posterior lumbar bladder acupoint massage on the regulation of serum interleukin-6(IL-6)and CHRM1 in patients with chronic fatigue syndrome(CFS),and provide theoretical basis for the treatment of CFS with cytokine level.Methods 60 cases of patients who met the CFS diagnostic criteria revised by the U.S.Centers for Disease Control and Prevention in 1994 were selected and randomly divided into massage group and acupuncture group,with30 cases each.Massage group was treated by posterior lumbar bladder acupoint massage,acupuncture group received acupuncture at back shu points.The evaluation values of FS-14,SAS,DSI before and after treatment of two groups and the changes of serum IL-6,CHRM1 content were observed.Results The quality of life in both groups was higher than that before treatment(P<0.05),massage group was superior to simple acupuncture in improving the clinical symptoms and health of CFS patients,relieving fatigue,and improving clinical efficacy,the difference was statistically significant(P<0.01);the serum levels of IL-6 and CHRM1 in the two groups were significantly lower before and after treatment(P<0.05,P<0.01);compared between the two groups,the level of IL-6 and CHRM1 in massage group was significantly lower(P<0.05).Conclusion Posterior lumbar bladder acupoint massage has better therapeutic effect on the patients with CFS,which is better than solely acupuncture,the mechanism may be related to the reduction of plasma IL-6 and CHRM1 content.