银杏叶制剂对缺血性脑卒中认知功能障碍患者血液流变学及神经保护作用的研究

Effect of Ginkgo Biloba Preparation on Hemorheology and Neuroprotection in Patients with Cognitive Impairment after Ischemic Stroke

目的观察银杏叶制剂对缺血性脑卒中认知功能障碍患者血液流变学及神经保护作用。方法选取本院收治的90例缺血性脑卒中认知功能障碍患者,按治疗方法不同分为两组各45例,对照组给予常规西药治疗,观察组在对照组治疗基础上加用银杏叶滴丸,治疗3个月后观察两组患者精神状态、生活能力、血液流变学及血清指标的变化。结果治疗后,两组患者蒙特利尔认知评估量表(MoCA)评分和日常生活活动能力量表(ADL)评分均呈明显增高(P<0.05),观察组上述评分均明显高于同期对照组(P<0.05);两组患者纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度均降低(P<0.05),两组患者上述指标组间比较差异有统计学意义(P<0.05);治疗后两组患者血清S100β蛋白、神经元特异性烯醇化酶(NSE)水平均降低,而血清脑源性神经细胞营养因子(BDNF)水平增高(P<0.05),两组上述指标组间比较均存在显著性差异(P<0.05);两组不良反应发生率比较无明显差异(P>0.05)。结论银杏叶制剂能有效改善缺血性脑卒中认知功能障碍患者精神状态和生活能力,并改善血液流变学而促进脑组织血供,促进损伤神经元的修复,具有较高的临床应用价值。

Objective To investigate the effects of ginkgo biloba preparation on hemorheology and neuroprotection in patients with cognitive dysfunction induced by ischemic stroke.Methods 90 cases of patients with cognitive dysfunction of ischemic stroke were divided into 2 groups according to different treatment methods,45 cases in each group.Control group was treated with conventional western medicine;observation group was treated with Ginkgo biloba drop pills on the basis of control group.The changes of mental state,living ability,hemorheology and serum index were observed in the two groups after 3 months of treatment.Results After treatment,the Montreal Cognitive Assessment(Mo CA)scores and Activity of Daily Living(ADL)scores of both groups were significantly increased(P<0.05),observation group were significantly higher than those of control group(P<0.05);the fibrinogen,plasma viscosity,whole blood low-cut viscosity and whole blood high-viscosity of both groups decreased(P<0.05),the difference between groups was statistically significant(P<0.05);serum S100βand neuron specific enolase(NSE)levels decreased,and serum brain-derived neurotrophic factor(BDNF)levels increased with significant difference(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo biloba preparation can effectively improve the mental state and living ability of patients with cognitive dysfunction after ischemic stroke,improve blood rheology and promote blood supply of brain tissue,and promote the repair of injured neurons.It has high clinical application value.