腔隙性脑梗死患者发生急性脑出血的相关因素Logistic回归分析

Logistic regression analysis of related factors of acute intracerebral hemorrhage in patients with lacunar infarction

目的探讨腔隙性脑梗死(Lacunar infarction,LI)患者发生急性脑出血的影响因素。方法选择2018年8月—2020年9月驻马店市第一人民医院收治的90例LI患者,统计所有患者急性脑出血发生情况;设计基线资料调查表,询问并记录患者确诊时基线资料及相关实验室指标,分析LI患者发生急性脑出血的影响因素。结果90例LI患者中发生急性脑出血31例,发生率为34.44%;发生组血清总胆固醇(TC)水平为(4.51±0.43)mmol/L,低于未发生组(5.12±0.56)mmol/L,同型半胱氨酸(Hcy)水平为(14.10±1.62)μmol/L,高于未发生组(10.48±1.01)μmol/L,差异均有统计学意义(t=5.295、13.036,P均<0.05);发生组合并高血压占比为51.61%(16/31),高于未发生组11.86%(7/59),差异有统计学意义(χ^(2)=16.877,P<0.05);经Logistic回归分析发现,合并高血压、血清Hcy水平高、TC水平低均可能为LI患者发生急性脑出血的影响因素(OR>1,P<0.05)。结论合并高血压、血清Hcy水平高、TC水平低的LI患者具有较高的急性脑出血发生风险,可能为LI患者发生急性脑出血的影响因素。

Objective To explore the influencing factors of acute intracerebral hemorrhage in patients with lacunar infarction(LI).Methods Totally 90 patients with LI treated in from August 2018 to September 2020 were selected,the occurrence of acute intracerebral hemorrhage in all patients was counted;Designed the baseline data questionnaire,asked and recorded the baseline data and relevant laboratory indexes of patients at the time of diagnosis,the influencing factors of acute intracerebral hemorrhage in patients with LI were analyzed.Results Among the 90 patients with LI,31 cases had acute intracerebral hemorrhage,the incidence rate was 34.44%;The level of serum total cholesterol(TC)in the occurrence group was(4.51±0.43)mmol/L,which was lower than that in the non occurrence group(5.12±0.56)mmol/L,the level of homocysteine(Hcy)was(14.10±1.62)μmol/L,higher than that in the non occurrence group(10.48±1.01)μmol/L,the differences were statistically significant(t=5.295,13.036,P<0.05);The proportion of combination with hypertension was 51.61%(16/31),which was higher than 11.86%(7/59)in the non occurrence group,the difference was statistically significant(χ^(2)=16.877,P<0.05);Logistic regression analysis showed that combination with hypertension,high serum Hcy level and low TC level might be the influencing factors of acute intracerebral hemorrhage in patients with LI(OR>1,P<0.05).Conclusion LI patients with combination with hypertension,high serum Hcy level and low TC level have a higher risk of acute intracerebral hemorrhage,which may be the influencing factor of acute intracerebral hemorrhage in patients with LI.