CIK联合TC方案治疗老年晚期卵巢癌的临床价值

Clinical value of CIK combined with TC in treatment of advanced ovarian cancer in the elderly

目的研究将细胞因子诱导的杀伤细胞(CIK)联合多西他赛联合卡铂(TC)方案应用于老年晚期卵巢癌患者中的作用与效果。方法选取2018年9月到2020年9月在郑州市第七人民医院就诊的老年晚期卵巢癌患者70例,按随机双盲法将患者分为两组,行TC方案治疗的35例作为对照组,另行CIK联合TC方案治疗的35例作为观察组;比较两组近期效果、免疫功能、生活质量及毒副反应。结果观察组客观有效率77.14%高于对照组的51.43%,生存质量改善率74.29%高于对照组的42.86%,差异有统计学意义(P<0.05)。观察组治疗后CD4^(+)、CD3^(+)、NK细胞高于对照组,CD8;低于对照组(P<0.05)。两组不良反应多为Ⅰ~Ⅱ级,经特殊处理后均好转,未出现相关性死亡。对比2组的不良反应的总发生率没有显著性的差异(P>0.05)。结论老年晚期卵巢癌治疗工作中应用CIK联合TC方案能够获得显著近期效果,患者免疫功能、生活质量显著改善,且不会提升毒副反应的总发生率,可以给临床中卵巢癌方面的治疗给予更多的参照,可应用与推广。

Objective To investigate the effects and functions of cytokine-induced killer cells(CIK)combined with docetaxel combined with carboplatin(TC)in elderly patients with advanced ovarian cancer.Methods Totally 70 elderly patients with advanced ovarian cancer who were admitted to our hospital from September 2018 to September 2020 were selected.The patients were divided into two groups according to the randomized double-blind method,35 cases treated with TC regimen were used as the control group,and 35 cases treated with CIK combined with TC regimen were used as the observation group.The short-term effects,immune function,quality of life and side effects were compared in the two groups.Results The objective effective rate of the observation group was 77.14%higher than that of the control group(51.43%),and the improvement rate of life quality was 74.29%higher than that of the control group(42.86%),the difference was statistically significant(P<0.05).After treatment,CD4^(+),CD3^(+) and NK cells in the observation group were higher than those in the control group,while CD8;cells were lower than those in the control group(P<0.05).Two groups of adverse reactions wereⅠ~Ⅱlevel,after special treatment were better,does not appear related to death.There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of CIK combined with TC in the treatment of advanced ovarian cancer in the elderly can achieve significant short-term effects,significantly improve the patients’immune function and quality of life,without increasing the total incidence of adverse reactions,which can provide more reference for the clinical treatment of ovarian cancer,and can be applied and promoted.