肺周围型占位性病变性质采用超声造影结合肿瘤标记物检测的研究

Study on effect of contrast-enhanced ultrasound combined with tumor markers in diagnosis of peripulmonary space-occupying lesions

目的分析肺周围型占位性病变性质采用超声造影与肿瘤标记物检测的作用与效果。方法信阳市中心医院2019年1月—2021年1月接受治疗的238例肺周围型占位性病变患者作为研究对象,患者均接受超声造影、肿瘤标记物检测,以病理结果为金标准,分析肿瘤标志物、超声造影诊断肺周围型占位性病变性质的效能,同时绘制ROC曲线,然后比较肿瘤标志物水平和超声造影表现结果。结果两组患者TPH、MTT比较差异无统计学意义(P>0.05);两组患者WIS、TTP、RT、PI、tAT、AT比较差异有统计学意义(P<0.05),且恶性组WIS、tAT、AT、PI均高于良性组,RT、TTP均低于恶性组,对比有统计学意义(P<0.05);tAT属于曲线下最大面积,而且当tAT超过2.5 s时,特异性为86.0%,因此tAT诊断肺周围型占位性病变性质有着最佳价值;恶性组CYFRA21-1水平、CEA水平、NSE水平均明显高于良性组,有统计学意义(P<0.05);两组患者血清肿瘤标志物比较有差异,且恶性组患者CYFRA21-1水平、CEA水平、NSE水平差异均有统计学意义(P<0.05)。结论肺周围型占位性病变性质采用肿瘤标记物检测与超声造影诊断准确性高,可以考虑积极推广。

Objective To analyze the effects of contrast-enhanced ultrasound(CEUS)and tumor markers.Methods From January 2019 to January 2021 during the treatment of 238 patients with pulmonary peripheral space-occupying lesion properties as the research object,the patients were received ultrasound imaging,tumor markers detection,with pathologic results as the gold standard,ultrasonic imaging performance,the patients with tumor markers level results comparison,the ROC curves are drawn at the same time,Then the efficacy of contrast-enhanced ultrasound(CEUS)and tumor marker water in diagnosing the nature of peripulmonary space-occupying lesions was analyzed.Results There were no differences in TPH and MTT between 2 groups(P>0.05).WIS,TTP,RT,PI,tAT and AT were different between the two groups,and the WIS,tAT,AT and PI in the malignant group were higher than those in the benign group,while RT and TTP were lower than those in the malignant group,P<0.05.TAT belongs to the largest area under the curve,and when the tAT exceeds 2.5 s,the specificity is 86.0%,so tAT has the best value in the diagnosis of peripulmonary space-occupying lesions.The levels of CYFRA21-1,CEA and NSE in malignant group were significantly higher than those in benign group(P<0.05).There were differences in serum tumor markers between the two groups,and the levels of CYFRA21-1,CEA and NSE in the malignant group were different.Conclusion CeUS and tumor markers are effective in the diagnosis of peripulmonary space-occupying lesions,and their effects are significant,which can be considered for active promotion.