氨糖软骨素钙片配合康复锻炼治疗早中期膝骨性关节炎

Chondroitin calcium tablets combined with rehabilitation exercise in treatment of early to mid-term knee osteoarthritis

目的探讨氨糖软骨素钙片配合康复锻炼对早中期膝骨性关节炎的疗效。方法2018年02月至2019年08收集月郑州市骨科医院门诊病例共179例,根据纳入及排除标准纳入病例共132例,根据随机数字法将患者分为两组:其中观察组66例,男29例,女37例,平均年龄为(65.1±7.2)岁,服用氨糖软骨素钙片2000mg/次,一日2次;对照组66例,男27例,女39例,平均年龄为(64.1±8.2)岁,服用塞来昔布胶囊200mg/次,一日2次。2组患者每天进行康复锻炼,锻炼方法:每天规律进行2次康复锻炼,每次时间30min。患者先散步10min,避免突然运动导致肌肉损伤,然后进行直腿抬高、坐位抬腿锻炼,每项15min。每隔2个月定期复查。比较两组患者治疗1年后膝关节活动度、行走50m时间、行走50m后VAS评分及膝关节周径。结果观察组患者的膝关节活动度(127.3°±13.3°)显著高于对照组患者(106.9°±7.4°)(P<0.05),行走50m疼痛VAS评分,观察组患者(2.29±0.59)显著低于对照组(3.91±0.43)(P<0.05),行走50m时间观察组(69.1±7.3)s也显著低于对照组(82.4±3.7)s(P<0.05)。结论氨糖软骨素钙片配合康复锻炼能有效治疗早中期膝关节骨性关节炎,能有效改善患者生活质量,延缓膝骨性关节炎进展。

Objective To explore the effect of chondroitin calcium tablet combined with rehabilitation exercise on early to mid-term knee osteoarthritis.Methods A total of 179 outpatients in Zhengzhou Orthopaedic Hospital from February 2018 to August 2019 were included,132 of whom were included according to inclusion and exclusion criteria.The patients were divided into two groups according to random number method:In the servation group,66 patients(29 males,37 females)with an average age of(65.1±7.2)years were given ammo glucose chondroitin calcium tablets 2000 mg/time,twice a day.In the control group,there were 66 patients(27 males,39 females)with an average age of(64.1±8.2)years.The control group was given celecoxib 200 mg/time,twice a day.Patients in the 2 groups received rehabilitation exercise every day.Exercise method:rehabilitation exercise was carried out regularly twice a day,each time for 30 min.The patient walked for 10 minutes to avoid muscle injury due to sudden movement,and then performed straight leg raising and sitting leg raising exercises for 15 minutes each.Check up regularly every 2 months.The range of knee motion,VAS score and knee circumference were compared between the two groups after 1 year of treatment,50 m walking time,and 50 m walking time.Results The range of motion of knee joint in the servation group,(127.3°±13.3°)was significantly higher than that in the control group(106.9°±7.4°)(P<0.05).The pain VAS score in the servation group,(2.29±0.59)was significantly lower than that in the control group(3.91±0.43)(P<0.05),and the time of walking 50 m of servation group(69.1±7.3)s was significantly lower than that of the control group(82.4±3.7)s(P<0.05).Conclusion Chondroitin calcium tablets combined with rehabilitation exercise can effectively treat Early to mid-term knee osteoarthritis,can effectively improve the quality of life of patients,delay the development of knee osteoarthritis.