高压氧治疗眉间纹注射玻尿酸致并发症的临床疗效分析

Clinical efficacy analysis of complications caused by hyaluronic acid injection for frown lines treated with hyperbaric oxygen therapy

目的探讨高压氧治疗眉间纹注射玻尿酸致并发症的治疗时机和最佳疗效。方法选取2020年5月~2023年5月哈尔滨医科大学附属第一医院高压氧科治疗的患者50例,均为眉间纹注射玻尿酸后出现不同程度红肿、感染和坏死等,经美容科溶栓后行高压氧治疗,对疗效与疗程进行观察。结果从溶栓后到接受高压氧治疗,病程在3天内有26例患者,其中21例患者注射部位红肿和瘀斑消失,痛感消失,痂皮基本脱落,5例患者注射部位红肿程度减轻、肿痛感减轻、瘀斑面积缩小、破损皮肤开始结痂,总有效率达100%;病程在7天内有18例患者,其中6例患者注射部位红肿和瘀斑消失、痛感消失,痂皮基本脱落,12例患者注射部位红肿程度减轻、痛感减轻、瘀斑面积缩小,破损皮肤开始结痂,总有效率达92%;病程在15天内有5例患者,其中1例患者注射部位红肿和瘀斑消失、痛感消失,痂皮基本脱落,3例患者注射部位红肿程度减轻、肿痛感减轻、瘀斑面积缩小、破损皮肤开始结痂,1例患者红肿程度、瘀斑面积或胀痛感无改善,总有效率达80%。治疗第1疗程12例,有效率82%;治疗第2疗程32例,有效率90%;治疗第3疗程6例,有效率69%。结论高压氧治疗眉间纹注射玻尿酸出现并发症,溶栓后立即进行高压氧治疗,疗效最好;且治疗效果在1周内显著。

Objective To investigate the timing and the optimal efficacy of hyperbaric oxygen(HBO)therapy for complications caused by hyaluronic acid injections for frown lines.Methods Fifty patients treated in department of hyperbaric oxygen in the First Affiliated Hospital of Harbin Medical University from May 2020 to May 2023 were selected,these patients had different degrees of redness,swelling,infection and necrosis after injection of hyaluronic acid for frown lines,and were treated with hyperbaric oxygen after thrombolytic therapy in the department of cosmetology.The treatment course and effectiveness were observed.Results From thrombolysis to hyperbaric oxygen treatment,26 patients were treated within 3 days,of which 21 patients disappeared erythema and ecchymosis at injection site,pain disappeared and scab basically fell off,and 5 patients reduced the degree of redness and swelling at injection site,the swelling and pain were relieved,the ecchymosis area was reduced and the damaged skin began to scab,the total effective rate was 100%.In the course of the disease,18 patients were treated within 7 days,of which 6 patients were treated with erythema and ecchymosis at the injection site disappeared,pain disappeared,and scab basically fell off;in 12 patients,the degree of redness and swelling at the injection site were reduced,swelling and pain were relieved,ecchymosis area was reduced,and damaged skin began to scab,with a total effective rate of 92%.Within 15 days,5 patients were treated,of which 1 patient disappeared erythema and ecchymosis at the injection site,pain disappeared,and scab basically fell off;3 patients reduced the degree of redness and swelling at the injection site,the sense of swelling and pain was reduced,the area of ecchymosis was reduced,and the damaged skin began to scab;1 patient had no improvement in the degree of redness and swelling,the area of ecchymosis or the sense of swelling and pain,and the total effective rate reached 80%.In the first course of treatment,12 patients had an effective rate of 82%;32 patients were treated in the second course,the effective rate was 90%;In the third course of treatment,6 patients had an effective rate of 69%.Conclusion Hyperbaric oxygen therapy is more effective when immediately administered after thrombolysis for complications arising from hyaluronic acid injections for frown lines,significant treatment outcomes typically observed with in one week.