放疗前NLR及TLC对局限期小细胞肺癌患者预后的分析

Prognostic significance of NLR and TLC in extensive-stage small-cell lung cancer

目的探索放疗前中性粒细胞与淋巴细胞比值和淋巴细胞总数评价局限期小细胞肺癌预后的预测价值。方法回顾性分析2013年1月~2016年1月确诊为局限期小细胞肺癌的142例患者资料。用Kaplan-Meier进行生存分析,用Log Rank进行非参数检验,单因素和Cox回归多因素分析NLR及TLC对总生存期影响。结果高NLR组及低NLR组的中位OS分别为19.00个月及35.00个月,差异存在统计学意义(P<0.05)。高TLC组及低TLC组的中位OS分别为32.27个月及19.00个月,差异存在统计学意义(P<0.05)。多因素分析NLR及TLC是总生存期的独立预后因素。结论放疗前NLR及TLC对评估局限期小细胞肺癌预后有一定的价值。

Objective To explore the ratio of neutrophils to lymphocytes,lymphocyte total in the evaluation of small cell lung cancer lung cancer prognosis predictive value.Methods The clinical data of 142 patients with limited-period small cell lung cancer from January 2013 to January 2016 were analyzed retrospectively.Survival analysis was carried out with kaplan-meier,non-parametric test was carried out with Log Rank,effect of NLR and TLC on the total lifetime was analyzed by single factor and Cox regression multi-factor analysis.Results The median OS of high NLR group and low NLR group were 19.00 months and 35.00 months respectively,with statistical significance(P<0.05).The median OS of high TLC group and low TLC group were 32.27 months and 19.00 months,respectively,with statistical significance(P<0.05).Multivariate analysis showed that NLR and TLC were independent prognostic factors for overall survival.Conclusion NLR and TLC before radiotherapy have certain value in evaluating the prognosis of small cell lung cancer with limited duration.