多氟芳烃的亲核反应 Ⅱ.一氯五氟苯的亲核环化

The Nucleophilic Reaction of Polyfluoroaromatic Compounds——Ⅱ.The Nucleophilic Cyclication of Chloropentafluorobenzene

本文报道一氯五氟苯与双官能团亲核试剂反应制备环化产物的研究结果,发现应用NaH-DMF体系制备醇钠,有利于亲核反应的顺利进行,环化产物产率有较大幅度提高.

The results of cyclization reaction between chloropentafluorobenzene andbifunctional nucleophiles such as XCH2CH2OH(X=OH,NHMe,NHEt)and HN(CH2CH2OH),NH2CH2CH2NH2 were reported.It was found that the NaH-DMF systemwas a better reagent for the preparation of sodium alcoholates and the yield s of cycliproducts ranged from 50—80%which were much higher than reported by previouworkers.