美丽红豆杉二萜的研究——Ⅰ.美丽红豆杉素A,B和C的结构测定

Studies on the Diterpenes from Taxus Mairei——I.Structures of Taxamairins A,B and C

从美丽红豆杉(Taxus mairei)的茎皮中分离得三个新的二萜化合物,其中美丽红豆杉素A(taxamairin A,1)和美丽红豆杉素B(taxamairin B,2)是含有(艹卓)酮的三环二萜,它们的骨架尚未见文献报道;美丽红豆杉素C(taxamairin C,3)是含有半缩酮的四环二萜.结构鉴定应用了高分辨的~1H NMR,C NMR~1H-~1H COSY和DFNOE等方法.美丽红豆杉素A的结构还通过X射线单晶衍射予以证实.

Three diterpones were isolated from the bark of Taxus mairei Lemee et Levl.S.Y.Hu collected in Fujian Province of China.Taxamairin A(1),B(2)and C(3)were proved to be new diterpenes.Thus,1 and 2 are tri(?)yclic-diterpenes containing a tropone ring system,while compound 3 is a tetracyclic-diterpene bearing a hemiketal moiety.These structures were elucidated on the basis of high resolution~1H NMR,C NMR,DFNOE and~1H-~1H COSY.The structure of 1 has been confirmed by X-ray diffraction analysis.