摘要
真菌的耐药性是近年来临床面临的一大严峻挑战。小檗碱对抗真菌方面表现出的较好耐药消减作用及各种植物病原真菌对其表现出较强的敏感性,使的小檗碱具有作为真菌感染临床治疗或抗真菌药物开发的巨大潜力。综述了小檗碱的抗真菌活性、作用机理及其分子探针的研究,预期为小檗碱类抗真菌药物的开发及相关研究提供参考。
The drug-resistance of fungi is a big challenge in recent years.Berberine has shown a good reduction against drug-resistance of fungi and is very sensitive to various plant pathogenic fungi,which indicates it has great potential in clinical treatment of fungal infection or development to an antifungal drugs.In this article,antifungal activity,action mechanism and molecular probe of berberine are systematically reviewed so as to provide references for the development and related studies of berberine antifungal drugs.
作者
韩永萍
刘红梅
李可意
王彤
葛喜珍
Han Yongping;Liu Hongmei;Li Keyi;Liu Jiarui;Ge Xizhen;Wang Tong(Beijing Key Laboratory of the Resource Utilization of Biomass Waste,Biochemical Engineering College,Beijing Union University,Beijing 100023,China)
出处
《化学世界》
CAS
CSCD
2020年第2期83-91,共9页
Chemical World
基金
北京联合大学人才强教优先(No.BPHR2018BZ01)资助项目.
关键词
小檗碱
抗真菌
机理
光亲和标记探针
berberine
antifungal
mechanism
photoaffinity labeling probe