中国中老年人胰岛素抵抗代谢评分与新发脑卒中相关性研究

Association study between Metabolic Insulin Resistance Score and New-Onset Stroke in middle-aged and elderly Chinese population

目的:探讨中老年人胰岛素抵抗代谢评分(METS-IR)与新发脑卒中之间的关系。方法:数据来源于2011年至2018年的中国健康与养老追踪调查(CHARLS)的数据。建立回归模型探究METS-IR与新发脑卒中之间的关联,同时采用限制立方样条模型来检查可能的非线性关联,并且采用亚组分析探究可能的潜在的调节变量。结果:研究共纳入6706名研究对象,其中新发脑卒中381人,回归模型结果发现METS-IR每上升一个四分位数,新发生脑卒中的患病风险增加67.3%(OR=1.673,95%CI:1.440~1.944)。使用限制性三次样条回归分析显示METS-IR与新发脑卒中患病率之间存在线性的相关关系,分层分析结果发现METS-IR与新发脑卒中的关系在不同亚组中一致。结论:METS-IR与新发脑卒中患病率密切相关,高METS-IR的人群需要更加警惕发生脑卒中的风险。

Objective Stroke is a major cause of cardiovascular mortality and may have a correlative relationship with insulin resistance.To investigate the relationship between the metabolic score for insulin resistance(METS-IR)and new-onset stroke in middle-aged and elderly people based on a large cohort study.Methods Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)in 2011 and 2018.Regression models were developed to explore the association between METS-IR and new-onset stroke,while restricted cubic spline models were used to examine possible nonlinear associations and subgroup analyses were used to explore possible potential moderating variables.Results A total of 6706 study subjects were included in the study,including 381 with new-onset stroke.The regression model results found a 67.3%increase in the risk of new-onset stroke for each quartile increase in the METS-IR(OR=1.673,95%CI:1.440-1.944).A linear relationship between the METS-IR and the prevalence of new-onset stroke was shown using restricted three-sample regression analysis,and stratified analysis revealed that the relationship between METS-IR and new-onset stroke was consistent across subgroups.Conclusion The METS-IR is strongly associated with the prevalence of new-onset stroke,and people with high METS-IR need to be more alert to the risk of stroke.